Metformin Impairs Vascular Endothelial Recovery After Stent Placement in the Setting of Locally Eluted Mammalian Target of Rapamycin Inhibitors Via S6 Kinase-Dependent Inhibition of Cell Proliferation

OBJECTIVES: This study sought to examine the effect of oral metformin (Mf) therapy on endothelialization in the setting of drug-eluting stents (DES). BACKGROUND: Mf is a commonly used therapy in diabetic patients receiving DES. Mf and locally eluted mammalian target of rapamycin (mTOR) inhibitors us...

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Autors principals: Habib, Anwer, Karmali, Vinit, Polavarapu, Rohini, Akahori, Hirokuni, Nakano, Masataka, Yazdani, Saami, Otsuka, Fumiyuki, Pachura, Kim, Davis, Talina, Narula, Jagat, Kolodgie, Frank D., Virmani, Renu, Finn, Aloke V.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942872/
https://ncbi.nlm.nih.gov/pubmed/23449430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2012.12.018
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