Hepcidin-ferroportin axis controls toll-like receptor 4 dependent macrophage inflammatory responses in human atherosclerotic plaques

OBJECTIVES: Toll-like Receptor 4 (TLR4) is implicated in modulating inflammatory cytokines though its role in atherosclerosis remains uncertain. We have recently described a non-foam cell macrophage phenotype driven by ingestion of hemoglobin:haptoglobin complexes (HH), via the scavenger receptor CD...

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Veröffentlicht in:Atherosclerosis
Hauptverfasser: Habib, Anwer, Polavarapu, Rohini, Karmali, Vinit, Guo, Liang, Van Dam, Richard, Cheng, Qi, Akahori, Hirokuni, Saeed, Omar, Nakano, Masataka, Pachura, Kimberly, Hong, Charles C., Shin, Eric, Kolodgie, Frank, Virmani, Renu, Finn, Aloke V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4795999/
https://ncbi.nlm.nih.gov/pubmed/26125411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2015.06.025
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