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Altered MicroRNA Processing in Heritable Pulmonary Arterial Hypertension: An Important Role for Smad-8
Rationale: Heritable pulmonary arterial hypertension (HPAH) is primarily caused by mutations of the bone morphogenetic protein (BMP) type-II receptor (BMPR2). Recent identification of mutations in the downstream mediator Smad-8 (gene, SMAD9) was surprising, because loss of Smad-8 function in canonic...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Thoracic Society
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3262031/ https://ncbi.nlm.nih.gov/pubmed/21920918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201106-1130OC |
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