Altered MicroRNA Processing in Heritable Pulmonary Arterial Hypertension: An Important Role for Smad-8

Rationale: Heritable pulmonary arterial hypertension (HPAH) is primarily caused by mutations of the bone morphogenetic protein (BMP) type-II receptor (BMPR2). Recent identification of mutations in the downstream mediator Smad-8 (gene, SMAD9) was surprising, because loss of Smad-8 function in canonic...

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Hlavní autoři: Drake, Kylie M., Zygmunt, Deborah, Mavrakis, Lori, Harbor, Phyllis, Wang, Lingli, Comhair, Suzy A., Erzurum, Serpil C., Aldred, Micheala A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262031/
https://ncbi.nlm.nih.gov/pubmed/21920918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201106-1130OC
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