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Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters

Adenovirus vector-based vaccine is a promising approach to protect HIV infection. However, a recent phase IIb clinical trial using the vector did not show its protective efficacy against HIV infection. To improve the vaccine, we explored the transgene protein expression and its immunogenicity using...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shoji, Masaki, Yoshizaki, Shinji, Mizuguchi, Hiroyuki, Okuda, Kenji, Shimada, Masaru
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261887/
https://ncbi.nlm.nih.gov/pubmed/22276174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030302
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