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Crucial roles for DNA ligase III in mitochondria but not in XRCC1-dependent repair
Mammalian cells have 3 ATP-dependent DNA ligases, which are required for DNA replication and repair(1). Homologs of ligase I (Lig1) and ligase IV (Lig4) are ubiquitous in eukarya, whereas ligase III (Lig3), which has nuclear and mitochondrial forms, appears to be restricted to vertebrates. Lig3 is i...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3261757/ https://ncbi.nlm.nih.gov/pubmed/21390132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09794 |
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