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Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA

Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR). Here, we present the cryo electron microscopy (cryo-EM) structure of the heterodimeric complex of the liganded human RXR and VDR bou...

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Sonraí Bibleagrafaíochta
Main Authors: Orlov, Igor, Rochel, Natacha, Moras, Dino, Klaholz, Bruno P
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261568/
https://ncbi.nlm.nih.gov/pubmed/22179700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.445
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