Human tRNA genes function as chromatin insulators

Insulators help separate active chromatin domains from silenced ones. In yeast, gene promoters act as insulators to block the spread of Sir and HP1 mediated silencing while in metazoans most insulators are multipartite autonomous entities. tDNAs are repetitive sequences dispersed throughout the huma...

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Bibliographic Details
Main Authors: Raab, Jesse R, Chiu, Jonathan, Zhu, Jingchun, Katzman, Sol, Kurukuti, Sreenivasulu, Wade, Paul A, Haussler, David, Kamakaka, Rohinton T
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261562/
https://ncbi.nlm.nih.gov/pubmed/22085927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.406
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