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An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence
In addition to acting as a transcriptional cofactor for p53, ASPP1 has been shown to function in the cytoplasm to regulate the nuclear localization and activity of YAP/TAZ. We show here that the ability of ASPP1 to activate YAP results in the decreased expression of LATS2, which lowers the ability o...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3261561/ https://ncbi.nlm.nih.gov/pubmed/22068052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.402 |
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