Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness

Increased ROS (cellular reactive oxygen species) are characteristic of both fibrosis and tumour development. ROS induce the trans-differentiation to myofibroblasts, the activated form of fibroblasts able to promote cancer progression. Here, we report the role of ROS produced in response to dysfuncti...

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Detalhes bibliográficos
Main Authors: Taddei, Maria Letizia, Giannoni, Elisa, Raugei, Giovanni, Scacco, Salvatore, Sardanelli, Anna Maria, Papa, Sergio, Chiarugi, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261495/
https://ncbi.nlm.nih.gov/pubmed/22272371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/684592
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