Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells

NK cells have therapeutic potential for a wide variety of human malignancies. However, because NK cells expand poorly in vitro, have limited life spans in vivo, and represent a small fraction of peripheral white blood cells, obtaining sufficient cell numbers is the major obstacle for NK-cell immunot...

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Bibliographische Detailangaben
Hauptverfasser: Denman, Cecele J., Senyukov, Vladimir V., Somanchi, Srinivas S., Phatarpekar, Prasad V., Kopp, Lisa M., Johnson, Jennifer L., Singh, Harjeet, Hurton, Lenka, Maiti, Sourindra N., Huls, M. Helen, Champlin, Richard E., Cooper, Laurence J. N., Lee, Dean A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261192/
https://ncbi.nlm.nih.gov/pubmed/22279576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030264
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