Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells

NK cells have therapeutic potential for a wide variety of human malignancies. However, because NK cells expand poorly in vitro, have limited life spans in vivo, and represent a small fraction of peripheral white blood cells, obtaining sufficient cell numbers is the major obstacle for NK-cell immunot...

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Hlavní autoři: Denman, Cecele J., Senyukov, Vladimir V., Somanchi, Srinivas S., Phatarpekar, Prasad V., Kopp, Lisa M., Johnson, Jennifer L., Singh, Harjeet, Hurton, Lenka, Maiti, Sourindra N., Huls, M. Helen, Champlin, Richard E., Cooper, Laurence J. N., Lee, Dean A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261192/
https://ncbi.nlm.nih.gov/pubmed/22279576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030264
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