The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer

BACKGROUND: Breast cancer (BrCa) is a complex disease driven by aberrant gene alterations and environmental factors. Recent studies reveal that abnormal epigenetic gene regulation also plays an important role in its pathogenesis. Ubiquitin carboxyl- terminal esterase L1 (UCHL1) is a tumor suppressor...

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Hauptverfasser: Xiang, Tingxiu, Li, Lili, Yin, Xuedong, Yuan, Chenfu, Tan, Cui, Su, Xianwei, Xiong, Lei, Putti, Thomas C., Oberst, Michael, Kelly, Kathleen, Ren, Guosheng, Tao, Qian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261155/
https://ncbi.nlm.nih.gov/pubmed/22279545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029783
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