Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)

BACKGROUND: Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in chronic murine models of experimental autoimmune encephalomyelitis (EAE) and th...

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Autores principales: Abbott, Derek J, Blanchfield, J Lori, Martinson, David A, Russell, Sean C, Taslim, Najla, Curtis, Alan D, Mannie, Mark D
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261124/
https://ncbi.nlm.nih.gov/pubmed/22208499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-12-72
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