GM-CSF-neuroantigen fusion proteins reverse experimental autoimmune encephalomyelitis and mediate tolerogenic activity in adjuvant-primed environments: association with inflammation-dependent, inhibitory antigen presentation()

Single-chain fusion proteins comprised of GM-CSF and neuroantigen (NAg) are potent, NAg-specific inhibitors of experimental autoimmune encephalomyelitis (EAE). An important question was whether GMCSF-NAg tolerogenic vaccines retained inhibitory activity within inflammatory environments or were conti...

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Detalhes bibliográficos
Main Authors: Islam, S.M. Touhidul, Curtis, Alan D., Taslim, Najla, Wilkinson, Daniel S., Mannie, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137761/
https://ncbi.nlm.nih.gov/pubmed/25049359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303223
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