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A GM-CSF-neuroantigen tolerogenic vaccine elicits inefficient antigen recognition events below the CD40L triggering threshold to expand CD4(+) CD25(+) FOXP3(+) Tregs that inhibit experimental autoimmune encephalomyelitis (EAE)

BACKGROUND: Tolerogenic vaccines represent antigen-specific interventions designed to re-establish self-tolerance and thereby alleviate autoimmune diseases, which collectively comprise over 100 chronic inflammatory diseases afflicting more than 20 million Americans. Tolerogenic vaccines comprised of...

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Библиографические подробности
Опубликовано в: :J Neuroinflammation
Главные авторы: Moorman, Cody D., Bastian, Alexander G., DeOca, Kayla B., Mannie, Mark D.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7285464/
https://ncbi.nlm.nih.gov/pubmed/32522287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01856-8
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