p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis

The p53 family member p73 is essential for brain development, but its precise role and scope remain unclear. Global p73 deficiency determines an overt and highly penetrant brain phenotype marked by cortical hypoplasia with ensuing hydrocephalus and hippocampal dysgenesis. The ΔNp73 isoform is known...

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Autori principali: Talos, F, Abraham, A, Vaseva, AV, Holembowski, L, Tsirka, SE, Scheel, A, Bode, D, Dobbelstein, M, Brück, W, Moll, UM
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260880/
https://ncbi.nlm.nih.gov/pubmed/21076477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.131
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