HIF-1α AND HIF-2α DEGRADATION IS DIFFERENTIALLY REGULATED IN NUCLEUS PULPOSUS CELLS OF THE INTERVERTEBRAL DISC

Studies of many cell types show that level of HIF-1α and HIF-2α is primarily controlled by oxygen-dependent proteasomal degradation, catalyzed by HIF prolyl-hydroxylases (PHDs). However, in hypoxic niche of the intervertebral disc, the mechanism of HIF-α turnover in nucleus pulposus cells is not yet...

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Hauptverfasser: Fujita, Nobuyuki, Chiba, Kazuhiro, Shapiro, Irving M., Risbud, Makarand V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260409/
https://ncbi.nlm.nih.gov/pubmed/21987385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.538
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