Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice

The tumour suppressor p53 transcriptionally regulates a range of target genes that control cell growth and survival. Mutations of p53 have been implicated in the development of ∼50% of human cancers, including those instigated by exposure to mutagens. Although numerically rare, cancers can arise as...

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Bibliografiske detaljer
Main Authors: Grabow, S, Waring, P, Happo, L, Cook, M, Mason, K D, Kelly, P N, Strasser, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260394/
https://ncbi.nlm.nih.gov/pubmed/21997189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.133
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