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The Location and Nature of General Anesthetic Binding Sites on the Active Conformation of Firefly Luciferase; A Time Resolved Photolabeling Study

Firefly luciferase is one of the few soluble proteins that is acted upon by a wide variety of general anesthetics and alcohols; they inhibit the ATP–driven production of light. We have used time–resolved photolabeling to locate the binding sites of alcohols during the initial light output, some 200...

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Bibliographic Details
Main Authors: Shanmugasundararaj, Sivananthaperumal, Lehle, Simon, Yamodo, Herve I., Husain, S. Shaukat, Tseng, Claire, Nguyen, Khanh, Addona, George H., Miller, Keith W.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260189/
https://ncbi.nlm.nih.gov/pubmed/22272253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029854
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