The Structure of the Glial Cell Line-derived Neurotrophic Factor-Coreceptor Complex: INSIGHTS INTO RET SIGNALING AND HEPARIN BINDING

Glial cell line-derived neurotrophic factor (GDNF), a neuronal survival factor, binds its co-receptor GDNF family receptor α1 (GFRα1) in a 2:2 ratio and signals through the receptor tyrosine kinase RET. We have solved the GDNF(2)·GFRα1(2) complex structure at 2.35 Å resolution in the presence of a h...

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Detalhes bibliográficos
Main Authors: Parkash, Vimal, Leppänen, Veli-Matti, Virtanen, Heidi, Jurvansuu, Jaana M., Bespalov, Maxim M., Sidorova, Yulia A., Runeberg-Roos, Pia, Saarma, Mart, Goldman, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259885/
https://ncbi.nlm.nih.gov/pubmed/18845535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802543200
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