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Arginines in the First Transmembrane Segment Promote Maturation of a P-glycoprotein Processing Mutant by Hydrogen Bond Interactions with Tyrosines in Transmembrane Segment 11

A key goal is to correct defective folding of mutant ATP binding cassette (ABC) transporters, as they cause diseases such as cystic fibrosis. P-glycoprotein (ABCB1) is a useful model system because introduction of an arginine at position 65 of the first transmembrane (TM) segment could repair foldin...

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Bibliografiske detaljer
Main Authors: Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259837/
https://ncbi.nlm.nih.gov/pubmed/18596043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803351200
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