Complete Loss of Post-translational Modifications Triggers Fibrillar Aggregation of SOD1 in the Familial Form of Amyotrophic Lateral Sclerosis

Dominant mutations in Cu,Zn-superoxide dismutase (SOD1) cause a familial form of amyotrophic lateral sclerosis (fALS), and aggregation of mutant SOD1 has been proposed to play a role in neurodegeneration. A growing body of evidence suggests that fALS-causing mutations destabilize the native structur...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Furukawa, Yoshiaki, Kaneko, Kumi, Yamanaka, Koji, O'Halloran, Thomas V., Nukina, Nobuyuki
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259764/
https://ncbi.nlm.nih.gov/pubmed/18552350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802083200
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