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A Pore-blocking Hydrophobic Motif at the Cytoplasmic Aperture of the Closed-state Na(v)1.7 Channel Is Disrupted by the Erythromelalgia-associated F1449V Mutation
Sodium channel Na(v)1.7 has recently elicited considerable interest as a key contributor to human pain. Gain-of-function mutations of Na(v)1.7 produce painful disorders, whereas loss-of-function Na(v)1.7 mutations produce insensitivity to pain. The inherited erythromelalgia Na(v)1.7/F1449V mutation,...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3259749/ https://ncbi.nlm.nih.gov/pubmed/18550534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802900200 |
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