ERK and the F-box Protein βTRCP Target STAT1 for Degradation

The transcription factor STAT1 has roles in development, homeostasis, cellular differentiation, and apoptosis and has been postulated to function as a tumor suppressor. STAT1 is activated by tyrosine or serine phosphorylation in response to specific cytokines or following a variety of stress-induced...

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Main Authors: Soond, Surinder M., Townsend, Paul A., Barry, Sean P., Knight, Richard A., Latchman, David S., Stephanou, Anastasis
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Mechanisms of Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259647/
https://ncbi.nlm.nih.gov/pubmed/18378670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800384200
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