STAT3 deletion sensitizes cells to oxidative stress

The transcription factor STAT1 plays a role in promoting apoptotic cell death, whereas the related STAT3 transcription factor protects cardiac myocytes from ischemia/reperfusion (I/R) injury or oxidative stress. Cytokines belonging to the IL-6 family activate the JAK-STAT3 pathway, but also activate...

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Main Authors: Barry, Seán P., Townsend, Paul A., McCormick, James, Knight, Richard A., Scarabelli, Tiziano M., Latchman, David S., Stephanou, Anastasis
Format: Artigo
Jezik:Inglês
Izdano: Academic Press 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706948/
https://ncbi.nlm.nih.gov/pubmed/19450559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.05.051
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