RAPAMYCIN-INDUCED TUMOR VASCULATURE REMODELING IN RHABDOMYOSARCOMA XENOGRAFTS INCREASES THE EFFECTIVENESS OF ADJUVANT IONIZING RADIATION

PURPOSE: Rapamycin inhibits vascular endothelial growth factor (VEGF) expression. VEGF is a tumor-elaborated protein that stimulates neovascularization. This inhibition can cause transient “normalization” of the generally dysfunctional tumor vasculature, resulting in improved tumor perfusion and oxy...

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Main Authors: Myers, Adrianne, Orr, Shannon, Denbo, Jason, Ng, Catherine, Zhou, Junfang, Spence, Yunyu, Wu, Jianrong, Davidoff, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259455/
https://ncbi.nlm.nih.gov/pubmed/22244414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpedsurg.2011.10.034
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