Enhancement of Airway Gene Transfer by DNA Nanoparticles Using a pH-Responsive Block Copolymer of Polyethylene Glycol and Poly-L-lysine

Highly compacted DNA nanoparticles, composed of single molecules of plasmid DNA compacted with block copolymers of polyethylene glycol and poly-L-lysine (PEG-CK(30)), have shown considerable promise in human gene therapy clinical trials in the nares, but may be less capable of transfecting cells tha...

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Detalhes bibliográficos
Main Authors: Boylan, Nicholas J., Kim, Anthony J., Suk, Jung Soo, Adstamongkonkul, Pichet, Simons, Brian W., Lai, Samuel K., Cooper, Mark J., Hanes, Justin
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259202/
https://ncbi.nlm.nih.gov/pubmed/22182747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2011.11.080
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