Bioluminescence Resonance Energy Transfer Assays Reveal Ligand-specific Conformational Changes within Preformed Signaling Complexes Containing δ-Opioid Receptors and Heterotrimeric G Proteins

Heptahelical receptors communicate extracellular information to the cytosolic compartment by binding an extensive variety of ligands. They do so through conformational changes that propagate to intracellular signaling partners as the receptor switches from a resting to an active conformation. This a...

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Autori principali: Audet, Nicolas, Galés, Céline, Archer-Lahlou, Élodie, Vallières, Marc, Schiller, Peter W., Bouvier, Michel, Pineyro, Graciela
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258885/
https://ncbi.nlm.nih.gov/pubmed/18381293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707941200
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