Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

We describe a microchip designed to quantify the levels of a dozen cytoplasmic and membrane proteins from single cells. We use the platform to assess protein–protein interactions associated with the EGF-receptor-mediated PI3K signaling pathway. Single-cell sensitivity is achieved by isolating a defi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Shi, Qihui, Qin, Lidong, Wei, Wei, Geng, Feng, Fan, Rong, Shik Shin, Young, Guo, Deliang, Hood, Leroy, Mischel, Paul S., Heath, James R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Physical Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258586/
https://ncbi.nlm.nih.gov/pubmed/22203961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110865109
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