Chromatin Insulator Elements Block Transgene Silencing in Engineered Human Embryonic Stem Cell Lines at a Defined Chromosome 13 Locus

Lineage reporters of human embryonic stem cell (hESC) lines are useful for differentiation studies and drug screening. Previously, we created reporter lines driven by an elongation factor 1 alpha (EF1α) promoter at a chromosome 13q32.3 locus in the hESC line WA09 and an abnormal hESC line BG01V in a...

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Detalhes bibliográficos
Main Authors: MacArthur, Chad C., Xue, Haipeng, Van Hoof, Dennis, Lieu, Pauline T., Dudas, Miroslav, Fontes, Andrew, Swistowski, Andrzej, Touboul, Thomas, Seerke, Rina, Laurent, Louise C., Loring, Jeanne F., German, Michael S., Zeng, Xianmin, Rao, Mahendra S., Lakshmipathy, Uma, Chesnut, Jonathan D., Liu, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2012
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258440/
https://ncbi.nlm.nih.gov/pubmed/21699412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2011.0163
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