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Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as the nucleus, but details about its biology and function in the organelle remain largely unknown. Here we show, using multiple approaches, that mammalian TERT is mitochondrial, co-purifying with mitochondrial nucl...

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Detalhes bibliográficos
Main Authors: Sharma, Nilesh K., Reyes, Aurelio, Green, Paula, Caron, Matthieu J., Bonini, Marcelo G., Gordon, Donna M., Holt, Ian J., Santos, Janine Hertzog
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258147/
https://ncbi.nlm.nih.gov/pubmed/21937513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr758
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