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Structural and Kinetic Isotope Effect Studies of Nicotinamidase (Pnc1) from S. cerevisiae

Nicotinamidases catalyze the hydrolysis of nicotinamide to nicotinic acid and ammonia. Nicotinamidases are absent in mammals but function in NAD(+) salvage in many bacteria, yeast, plants, protozoa, and metazoans. We have performed structural and kinetic investigations of the nicotinamidase from S....

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Autors principals: Smith, Brian C., Anderson, Mark A., Hoadley, Kelly A., Keck, James L., Cleland, W. Wallace, Denu, John M.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257521/
https://ncbi.nlm.nih.gov/pubmed/22229411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2015508
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