Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties

6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), a key enzyme in the folate biosynthetic pathway, catalyzes the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin. The enzyme is essential for microorganisms, is absent from humans, and is not the target for any existing...

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Autores principales: Shi, Genbin, Shaw, Gary, Liang, Yu-He, Subburaman, Priadarsini, Li, Yue, Wu, Yan, Yan, Honggao, Ji, Xinhua
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257516/
https://ncbi.nlm.nih.gov/pubmed/22169600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.11.032
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