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Alloimmunization to transfused platelets requires priming of CD4(+) T cells in the splenic microenvironment in a murine model

BACKGROUND: Alloantibodies are a clinically significant sequelae of platelet transfusion, potentially rendering patients refractory to ongoing platelet transfusion support. These antibodies are often IgG class switched, suggesting the involvement of CD4(+) T cell help; however, platelet specific CD4...

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Detalhes bibliográficos
Main Authors: Gilson, Christopher R, Zimring, James C
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257367/
https://ncbi.nlm.nih.gov/pubmed/21981241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1537-2995.2011.03346.x
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