Revealing a steroid receptor ligand as a unique PPARγ agonist

Peroxisome proliferator-activated receptor gamma (PPARγ) regulates metabolic homeostasis and is a molecular target for anti-diabetic drugs. We report here the identification of a steroid receptor ligand, RU-486, as an unexpected PPARγ agonist, thereby uncovering a novel signaling route for this ster...

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Autori principali: Lin, Shengchen, Han, Ying, Shi, Yuzhe, Rong, Hui, Zheng, Songyang, Jin, Shikan, Lin, Shu-Yong, Lin, Sheng-Cai, Li, Yong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257359/
https://ncbi.nlm.nih.gov/pubmed/21986665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.162
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