Crystal Structure of a Human Single Domain Antibody Dimer Formed through V(H)-V(H) Non-Covalent Interactions

Single-domain antibodies (sdAbs) derived from human V(H) are considered to be less soluble and prone to aggregate which makes it difficult to determine the crystal structures. In this study, we isolated and characterized two anti-human epidermal growth factor receptor-2 (HER2) sdAbs, Gr3 and Gr6, fr...

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Detalhes bibliográficos
Main Authors: Baral, Toya Nath, Chao, Shi-Yu, Li, Shenghua, Tanha, Jamshid, Arbabi-Ghahroudi, Mehdi, Zhang, Jianbing, Wang, Shuying
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257273/
https://ncbi.nlm.nih.gov/pubmed/22253912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030149
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