CTNNB1 Signaling in Sertoli Cells Downregulates Spermatogonial Stem Cell Activity via WNT4

Constitutive activation of the WNT signaling effector CTNNB1 (β-catenin) in the Sertoli cells of the Ctnnb1 (tm1Mmt/+);Amhr2 (tm3(cre)Bhr/+) mouse model results in progressive germ cell loss and sterility. In this study, we sought to determine if this phenotype could be due to a loss of spermatogoni...

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Detalles Bibliográficos
Main Authors: Boyer, Alexandre, Yeh, Jonathan R., Zhang, Xiangfan, Paquet, Marilène, Gaudin, Aurore, Nagano, Makoto C., Boerboom, Derek
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257228/
https://ncbi.nlm.nih.gov/pubmed/22253774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029764
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