Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

Adjuvants are critical for the success of vaccines. Agonists of microbial pattern recognition receptors (PRRs) are promising new adjuvant candidates. A mechanism through which adjuvants enhance immune responses is to stimulate innate immunity. We studied the innate immune response in humans to synth...

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Dades bibliogràfiques
Autors principals: Caskey, Marina, Lefebvre, François, Filali-Mouhim, Abdelali, Cameron, Mark J., Goulet, Jean-Philippe, Haddad, Elias K., Breton, Gaëlle, Trumpfheller, Christine, Pollak, Sarah, Shimeliovich, Irina, Duque-Alarcon, Angela, Pan, Li, Nelkenbaum, Annette, Salazar, Andres M., Schlesinger, Sarah J., Steinman, Ralph M., Sékaly, Rafick P.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2011
Matèries:
Brief Definitive Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256967/
https://ncbi.nlm.nih.gov/pubmed/22065672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111171
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