Structure of Myostatin·Follistatin-like 3: N-TERMINAL DOMAINS OF FOLLISTATIN-TYPE MOLECULES EXHIBIT ALTERNATE MODES OF BINDING

TGF-β family ligands are involved in a variety of critical physiological processes. For instance, the TGF-β ligand myostatin is a staunch negative regulator of muscle growth and a therapeutic target for muscle-wasting disorders. Therefore, it is important to understand the molecular mechanisms of TG...

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Bibliographic Details
Main Authors: Cash, Jennifer N., Angerman, Elizabeth B., Kattamuri, Chandramohan, Nolan, Kristof, Zhao, Huaying, Sidis, Yisrael, Keutmann, Henry T., Thompson, Thomas B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256893/
https://ncbi.nlm.nih.gov/pubmed/22052913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.270801
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