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Alternative Binding Modes Identified for Growth and Differentiation Factor-associated Serum Protein (GASP) Family Antagonism of Myostatin

Myostatin, a member of the TGF-β family of ligands, is a strong negative regulator of muscle growth. As such, it is a prime therapeutic target for muscle wasting disorders. Similar to other TGF-β family ligands, myostatin is neutralized by binding one of a number of structurally diverse antagonists....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Walker, Ryan G., Angerman, Elizabeth B., Kattamuri, Chandramohan, Lee, Yun-Sil, Lee, Se-Jin, Thompson, Thomas B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367259/
https://ncbi.nlm.nih.gov/pubmed/25657005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.624130
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