Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin

FOXO3a is a forkhead transcription factor that regulates a multitude of important cellular processes, including proliferation, apoptosis, differentiation, and metabolism. Doxorubicin treatment of MCF-7 breast carcinoma cells results in FOXO3a nuclear relocation and the induction of the stress-activa...

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Bibliografiske detaljer
Main Authors: Ho, Ka-Kei, McGuire, Victoria A., Koo, Chuay-Yeng, Muir, Kyle W., de Olano, Natalia, Maifoshie, Evie, Kelly, Douglas J., McGovern, Ursula B., Monteiro, Lara J., Gomes, Ana R., Nebreda, Angel R., Campbell, David G., Arthur, J. Simon C., Lam, Eric W.-F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256863/
https://ncbi.nlm.nih.gov/pubmed/22128155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.284224
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