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Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic
Protein kinases are activated by phosphorylation and by the binding of activator proteins. The interplay of these two factors is incompletely understood. We applied energetic analysis to this question and characterized the activation process of the serine/threonine kinase Aurora-A by phosphorylation...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3256853/ https://ncbi.nlm.nih.gov/pubmed/22094468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.312090 |
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