Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization

Clinical, pharmacological, biochemical, and genetic evidence support the notion that alteration of cholesterol homeostasis strongly predisposes to Alzheimer disease (AD). The ATP-binding cassette transporter-2 (Abca2), which plays a role in intracellular sterol trafficking, has been genetically link...

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Main Authors: Michaki, Vasiliki, Guix, Francesc X., Vennekens, Krist'l, Munck, Sebastian, Dingwall, Colin, Davis, John B., Townsend, Danyelle M., Tew, Kenneth D., Feiguin, Fabian, De Strooper, Bart, Dotti, Carlos G., Wahle, Tina
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256850/
https://ncbi.nlm.nih.gov/pubmed/22086926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288258
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