Functional Blockade of the Voltage-gated Potassium Channel Kv1.3 Mediates Reversion of T Effector to Central Memory Lymphocytes through SMAD3/p21(cip1) Signaling

The maintenance of T cell memory is critical for the development of rapid recall responses to pathogens, but may also have the undesired side effect of clonal expansion of T effector memory (T(EM)) cells in chronic autoimmune diseases. The mechanisms by which lineage differentiation of T cells is co...

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Bibliographic Details
Main Authors: Hu, Lina, Gocke, Anne R., Knapp, Edward, Rosenzweig, Jason M., Grishkan, Inna V., Baxi, Emily G., Zhang, Hao, Margolick, Joseph B., Whartenby, Katharine A., Calabresi, Peter A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256849/
https://ncbi.nlm.nih.gov/pubmed/22110135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.296798
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