Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

B cells are central to the pathogenesis of granulomatosis with polyangiitis (GPA), exhibiting both (auto)antibody-dependent and -independent properties. Class-switched memory B cells in particular are a major source of pathogenic autoantibodies. These cells are characterized by high expression level...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Land, Judith, Lintermans, Lucas L., Stegeman, Coen A., Muñoz-Elías, Ernesto J., Tarcha, Eric J., Iadonato, Shawn P., Heeringa, Peter, Rutgers, Abraham, Abdulahad, Wayel H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622953/
https://ncbi.nlm.nih.gov/pubmed/29018452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01205
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