Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice

BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparing components of fear conditioning. BDNF-tg mice also display...

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Autors principals: Papaleo, Francesco, Silverman, Jill L., Aney, Jordan, Tian, Qingjun, Barkan, Charlotte L., Chadman, Kathryn K., Crawley, Jacqueline N.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256571/
https://ncbi.nlm.nih.gov/pubmed/21791566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.2213711
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