Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice

BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparing components of fear conditioning. BDNF-tg mice also display...

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Detalhes bibliográficos
Main Authors: Papaleo, Francesco, Silverman, Jill L., Aney, Jordan, Tian, Qingjun, Barkan, Charlotte L., Chadman, Kathryn K., Crawley, Jacqueline N.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256571/
https://ncbi.nlm.nih.gov/pubmed/21791566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.2213711
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