Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice

BDNF regulates components of cognitive processes and has been implicated in psychiatric disorders. Here we report that genetic overexpression of the BDNF mature isoform (BDNF-tg) in female mice impaired working memory functions while sparing components of fear conditioning. BDNF-tg mice also display...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Papaleo, Francesco, Silverman, Jill L., Aney, Jordan, Tian, Qingjun, Barkan, Charlotte L., Chadman, Kathryn K., Crawley, Jacqueline N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2011
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256571/
https://ncbi.nlm.nih.gov/pubmed/21791566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.2213711
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