Histone Deacetylase Inhibitors Globally Enhance H3/H4 Tail Acetylation Without Affecting H3 Lysine 56 Acetylation

Histone deacetylase inhibitors (HDACi) represent a promising avenue for cancer therapy. We applied mass spectrometry (MS) to determine the impact of clinically relevant HDACi on global levels of histone acetylation. Intact histone profiling revealed that the HDACi SAHA and MS-275 globally increased...

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Main Authors: Drogaris, Paul, Villeneuve, Valérie, Pomiès, Christelle, Lee, Eun-Hye, Bourdeau, Véronique, Bonneil, Éric, Ferbeyre, Gerardo, Verreault, Alain, Thibault, Pierre
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256565/
https://ncbi.nlm.nih.gov/pubmed/22355734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00220
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