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Conditional and Specific Inhibition of NF-κB in Mouse Pancreatic β Cells Prevents Cytokine-Induced Deleterious Effects and Improves Islet Survival Post-Transplant

BACKGROUND: Islets are susceptible to damage by proinflammatory cytokines, via activation of transcription factor NF-κB. We hypothesized that inhibition of NF-κB activity will decrease cytokine-mediated β cell injury and improve islet transplant functional outcome. METHODS: We created a transgenic m...

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Detalhes bibliográficos
Main Authors: Rink, Jonathan S., Chen, Xiaojuan, Zhang, Xiaomin, Kaufman, Dixon B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256254/
https://ncbi.nlm.nih.gov/pubmed/21982523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2011.07.011
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