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Conditional and Specific Inhibition of NF-κB in Mouse Pancreatic β Cells Prevents Cytokine-Induced Deleterious Effects and Improves Islet Survival Post-Transplant
BACKGROUND: Islets are susceptible to damage by proinflammatory cytokines, via activation of transcription factor NF-κB. We hypothesized that inhibition of NF-κB activity will decrease cytokine-mediated β cell injury and improve islet transplant functional outcome. METHODS: We created a transgenic m...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3256254/ https://ncbi.nlm.nih.gov/pubmed/21982523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2011.07.011 |
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